Cell-cell signaling communication is a key event during development and has to occur in a precise manner; its misregulation is one of the most prevalent causes of diseases such as cancer, congenital malformations and neurological disorders. The group demonstrates a direct-delivery of one of the above key signaling molecules, Hedgehog, through specialized filopodia (also called cytonemes). This mechanism facilitates concentration and spatial restriction of a signal in a short and long distance communication (Bischoff et al., Nat. Cell. Biol. 2013). More recently the group demonstrate that exosomes are the Hedgehog carriers in cytoneme-mediated transport and secretion. (Gradilla et al., Nat. Comm. 2014).

Top